Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles.
نویسندگان
چکیده
The Fe(3)O(4) nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 131 1 شماره
صفحات -
تاریخ انتشار 2009